Hours Safeway - El Camino Real & Spruce Ave, South San Francisco, CA
Holiday Hours 2026 Show
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Safeway lies at 190 El Camino Real, in the south-west region of South San Francisco (not far from San Bruno Station). This store serves the customers of San Francisco, San Bruno, Brisbane, Millbrae, Daly City, Burlingame and Pacifica. It is open today (Sunday) from 5:00 am until 2:00 am. Refer to this page for the specifics on Safeway El Camino Real & Spruce Ave, South San Francisco, CA, including the operating times, location details, product ranges and further information.
Visit your local Safeway branch not far from the intersection of South Spruce Avenue and El Camino Real, in South San Francisco, California.
1 minute drive from Brentwood Drive, Hazelwood Drive, Rockwood Drive or Exit 5 (Quentin L. Kopp Freeway) of I-380; a 3 minute drive from Exit 424 (Bayshore Freeway) of US-101, Junipero Serra Freeway (I-280) and Bayshore Freeway (US-101); and a 8 minute drive from US-101-Spur or Exit 43A (Junipero Serra Freeway) of I-280.
Address for route finder devices - 190 El Camino Real, South San Francisco, CA 94080.
You can catch the bus directly to El Camino Real & Brentwood Drive and Huntington Avenue & Spruce Avenue. You can get here by lines 142, ECR or ECR Owl.
Services run regularly to San Bruno Station (3080 ft) and South San Francisco Station (2.05 mi away). Your line options: Richmond– Daly City/ Millbrae and Pittsburg/Bay Point–SFO/Millbrae.
Train stops: San Bruno Station (1.24 mi) and South San Francisco Station (1.50 mi away). Via the line: Caltrain.
There are other interesting places nearby, including South San Francisco Center, Francisco Terrace Playlot, San Bruno Towne Center, Tanforan Professional Center, Golden Gate National Cemetery and Brentwood Center.
There is presently a total number of 3 Safeway supermarkets open in South San Francisco.
For the entire index of all Safeway grocery stores near South San Francisco, visit the following page.